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What is a Customized Screening?
The 3D models are more representative of in vivo tumors than monolayer cell cultures and are used to enhance drug screening prediction before animal testing
(3R Rule: Reduce, Refine, Replace).
Our 3D models called Artificial Tumors® are produced in monoculture (one type of cell line) to allow HighThroughput processes and a high level of reproducibility.
Their production and culture parameters (compaction, size, proliferation curves) are highly reproducible (<10% variation) and allow easy and rapid screening procedures.
The High-Throughput Screening on 3D models is
already available for the following cell lines :
BREAST CANCER
MDA-MB-231
Triple negative breast cancer
(ER-, PR-, HER2- and EGFR+).
SUM1315
Triple negative breast cancer
(ER-, PR-, HER2- and EGFR+).
HCC1937
Triple negative breast cancer
(ER-, PR-, HER2- and EGFR+).
SW527
Triple negative breast cancer
(ER-, PR- and HER2-)
CAL51
Triple negative breast cancer
(ER-, PR- and HER2-)
MCF-7
Luminal A breast cancer cell line
(ER+, PR+ et HER2-)
BT-474
Luminal B breast cancer cell line
(ER+, PR+ et HER2+)
OVARIAN CANCER
SK-OV-3
Non-HGSC ovarian cancer cell line
(High Grade Serious Carcinoma) (HER2+)
PROSTATE CANCER
PC-3
Prostatic cancer cell line (AR-)
LUNG CANCER
NCI-H1975
Non-small cell lung cancer cell line
(T790M mutation)
Watch our video about screening service (english subtitles available)
Customized screening: what can we test with our 3D models ?
What is a customized
medium development?
OptiPASS® is a brand of culture media serum-free, complete and ready to use. They are adapted to the culture of several 2D or 3D models and for cell conservation without freezing.
With serum-free medium cultures, the cells may need adapted and specific formulations to obtain optimal growth and maintain cell phenotype.
Thanks to our culture medium expert, we can adapt the formulation of OptiPASS to your specific cell type.
What is a customized
medium development?
The formulation of medium is a crucial point for optimal cell culture. The cells need specific components in a well-known concentration to have an optimal growth and culture.
OptiPASS® is a serum-free, complete and complex medium. It can be used for 2D or 3D validated culture models.
Customized medium development allows to produce adapted OptiPASS® for the growth of interest cells.
What is a
customized
3D cell culture
model?
3D models reproduce precisely the tumor microenvironment, especially for oncology in vitro preclinical modeling.
The development and validation of these models is time consuming and requires specific process and expertise. We share this expertise for the custom development of your 3D models.
Once the development is complete, we can propose two types of services:
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